Living EuroGuiDerm Guideline for the systemic treatment of Atopic Eczema

Download entire guideline in the most up-to-date version:

Last updated
Updated 2025
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Introduction, scoping, population and targeted users
06/2022
Original version
Treatment and treatment goals definitions
06/2022
Original version
Methods Section
01/2026
New information on update
Treatment algorithm (adults + children/adolescents)
01/2026
New voting on the level of systemic treatment
Overview tables
01/2026
New voting on systemic treatment
Implementation slidekit
01/2026
Slides with updated and new recommendations, updated treatment algorithms and updated overview tables

Last updated
Updated 2025
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Basic emollients and moisturizers
06/2022
Original version
Antiinflammatory treatment
06/2022
Original version
Antimicrobial treatment
06/2022
Original version

Last updated
Updated 2025
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Antipruritic treatment
06/2022
Original version

Last updated
Updated 2025
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Phototherapy and photochemotherapy
06/2022
Original version

Last updated
Updated 2025
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Introduction to systemic treatment
01/2026
New guidance on vaccination, treatment switching, adaption of frequency and interval
Azathioprine
01/2026
Deletion of the recommendation; minor adjustments to the background text
Ciclosporin
01/2026
New voting; minor adjustments to the background text
Systemic glucocorticosteroids
01/2026
New voting; minor adjustments to the background text
Methotrexate
01/2026
New voting; minor adjustments to the background text
Dupilumab
01/2026
New voting; minor adjustments to the background text
Lebrikizumab
01/2026
New voting; minor adjustments to the background text
Nemolizumab
01/2026
New voting; minor adjustments to the background text
Tralokinumab
01/2026
New voting; minor adjustments to the background text
JAK-Inhibitors introduction
01/2026
Minor adjustments to the background text
Abrocitinib
01/2026
New voting; minor adjustments to the background text
Baricitinib
01/2026
New voting; minor adjustments to the background text
Upadacitinib
04/2026
Clarification
Other systemic treatment
01/2026
Deletion of alitretinoin recommendation; adjustments to the background text
Therapies that were used in past
01/2026
MMF added; omalizumab added

Last updated
Updated 2025
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Patient's perspective
06/2022
Original version
Avoidance techniques in atopic eczema
06/2022
Original version
Dietary interventions in atopic eczema
06/2022
Original version
Allergen-specific immunotherapy
06/2022
Original version
Complementary medicine
06/2022
Original version
Psychological and educational interventions
06/2022
Original version
Occupational aspects
06/2022
Original version

Last updated
Updated 2025
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Pregnancy, breastfeeding, wish for child
01/2026
Updated recommendations and background text
Considerations for paediatric and adolescent patients
06/2022
Original version

Last updated
Updated 2025
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Strengths and limitations
06/2022
Original version
Methods Report
12/2025
New information on update
Evidence Report
04/2025
Updated evidence
Guideline
Previous guideline 2018

Last updated
Updated 2025
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Appendix: Antimicrobial treatment
10/2022
Original version
Appendix: Phototherapy and Photochemotherapy
10/2022
Original version